The research on cell therapy is done to evolve better therapeutic outcomes of regenerative therapies and clinical trials. The advance knowledge of stem cell research & therapy helps to bring a positive impact on patients with neuromuscular disorders.
The Topics Covered in Stem Cell Research Include:
- The potential of the stem cells such as self-renewal, differentiation, and cell-reprogramming
- The stem cell research explores their regenerative properties in the tissue microenvironment
- Investigate the therapeutic potential of stem cells such as endogenous or exogenous stem cells for skeletal reconstruction
- To explore the biomaterials and organoid possibilities of stem cells as a regenerative medicine
- To prove the therapeutic applications of cell treatment
- To gain in-depth knowledge on the therapeutic potential of paracrine factors such as cytokines
According to stem cell research & therapy, stem cells can develop into many different cell types. Serving as a repair possibility, they divide without limit to replenish the space of the dead or damaged cells for as long as the person is still alive. As they divide, each ‘daughter’ cell either remain a stem cell or develop into a cell with a specialized function, such as a brain cell or a muscle cell.
The stem cells are categorized as autologous stem cells (derived from the patient), and the donor stem cells (collected from a donor). Mesenchymal stem cells also known as multipotent mesenchymal stromal cells, are found in the bone marrow tissues. Stem cell research & therapy have proved that these self‐renewing cells have the potential to differentiation into hepatocytes and their immunomodulatory characteristics. Thus, the bone marrow-derived autologous stem cells are considered as a promising therapeutic agent due to their regenerative and immunomodulatory characteristics.
Research On Treating Neurological Disorders With Stem Cells
Disorder or damage of the central nervous system (brain and spinal cord) develop into problems which include:
- Sleepiness
- Poor concentration
- Loss of memory and cognition skill
- Problems learning tasks
- Confusion and depression
- Loss of fine and gross motor control
According to research, neurodegenerative disorders result due to gene mutation and damage to brain tissues. This affects the adequate supply of oxygenated blood flow to the damaged area, resulting in cell death. The intrathecally engrafted autologous stem cells merge with the cerebrospinal fluid and migrate toward the damaged area. These cells have the angiogenetic and immunomodulatory properties along with various neuroprotective effects. Thus, cell therapy with bone marrow stem cells can alleviate many complex neurological disorders.
NeuroGen Brain and Spine Institute, situated in Mumbai, provides the best treatment with stem cells for many degenerative disorders. Headed by Dr Alok Sharma, a renowned neuroscientist, professor, and neurosurgeon and has extensive surgical expertise in neurosurgery and stem cells. He authored 14 books, textbooks, produced neurosurgical films and over 100 publications to his credit. Also awarded as the ‘Best Stem Cell Research Hospital in India’ by Dr Anupriya Patel in November 2018.
