Muscular dystrophies are a group of genetic diseases marked by progressive weakening of skeletal muscles. Duchenne muscular dystrophy (DMD), is a type of muscular disorder caused because of the absence of dystrophin. Lack of this protein easily damages the body muscles leading to inflammation that causes further deterioration of the muscle tissue. The best way to treat patients is to visit NeuroGen Brain and Spine Institute, also known as one of the best Duchenne muscular dystrophy treatment centers in India.
Duchenne muscular dystrophy is caused by mutations of the gene that produces dystrophin. Loss of dystrophin is the reason behind dysfunctional cell processes. This leads to progressive muscle waning and wasting of the skeletal muscles responsible for voluntary body movements.
Why Is Cell Treatment Effective?
Muscles are made of several muscle fibres containing many nuclei including stem cells. These stem cells create cells called myoblast to repair impaired muscle fibres. However, in individuals with Duchenne muscular dystrophy, these cells fail to produce enough myoblasts. This ultimately leads to rapid damage to the muscles.
Stem cells have the property to multiply and also differentiate into various cell types. They are apt at replacing the dead or damaged tissue cells to regain healthy muscle tone. Duchenne muscular dystrophy treatment centres in India harness the stem cells extracted from the bone marrow of the patients. The main goal of autologous cell therapy for Duchenne muscular dystrophy is to replenish the muscle stem cells with sufficient dystrophin-competent cells.
Procedure
There is no complete cure for Duchenne muscular dystrophy, however, treatment done with mesenchymal stem cells is focused on controlling the symptoms and reviving the muscle strength. NeuroGen Brain and Spine Institute is one of the well-known Duchenne muscular dystrophy treatment centers in India that offers cell treatment via autologous stem cells. This regenerative cell therapy is effective and safe. It involves three simple steps to bring about an amazing transformation in patients within a few months after treatment.
Initially, under a hygienic environment of the operation theatre, bone marrow is extracted from the hip bone of the patient. The extraction is done with a marrow aspiration needle pierced at the required spot. For the second step, the marrow tissue is shifted to the well-equipped laboratory of the hospital. Here the robust stem cells are separated from the marrow with density gradient centrifugation procedure. The concluding step is the infusion of the acquired stem cells. Using a very fine needle, the neurosurgeons inject the cells into the muscle points of patients with muscular dystrophy.
Once inside the muscles, the infused stem cells move towards the area of damage with the help of chemical signals emitted by the impaired cells. They fuse with muscle tissues to form new muscle fibres. The stem cells produce multiple cells to ensure the continuous replacement of muscle cells in the future.
The advantage of treating patients using autologous stem cell transplants is that there is no chance of rejection by the body’s immune system.
