The Autism Spectrum Disorders (ASDs) affect the Neurodevelopmental aspects, and can be heterogeneous, complex, and severe. Autism and ASDs are characterized by dysfunctions related to communication and social interaction skills, stereotype and restrictive behavior, and abnormalities that are concerned with the verbal and nonverbal behavior. The cellular and biochemical adverse events that are associated with the disease include stress (including reticulum and oxidative stress), lower methylation capacity, low glutathione production, dysfunctions associated with the mitochondria, the greater burden of toxic metals, immune system deregulation, inflammation, and other abnormalities.
Stem Cells in Autism Spectrum Disorders
Stem cells are considered the future of regenerative and molecular medicine. They can treat the conditions that cannot be treated by medications, surgery, or the rehabilitation techniques. The desirable, “patient specific” therapies, can also be developed by the use of stem cells. The specific target of a stem cell autism treatment therapy is the neural and immune deregulation. The usefulness of stem cells emanates out of their peculiar characteristics.
Self-Renewal:
Stem cells can divide to form any number of identical cells.
Differentiation:
Stem cells can divide to form the specialized cells. The differentiated and specialized cells, like the neurons and blood vessels can undertake the vital and important functions of the body.
Paracrine Regulation:
The stem cells synthesize within themselves a group of substances that are termed as “bio-pharmacy.” The substances, when released, regulate the differentiation of cells, aid organ, and tissue repair, and also lower the inflammation.
The 2 bio-pharmacies of stem cells, including immunomodulatory and trophic biomolecules, can be isolated in-vitro, and can be used in the form of therapeutic agents, without cellular transplantation. Both, the donor and autologous cells, can affect the immune system of the recipient positively through 2 mechanisms:
Through the “cell to cell” contact: The pro-inflammatory macrophages get converted to the anti-inflammatory macrophages, by the stem cells, via this method.
Paracrine Secretome activity:
As the ASDs are characterized by a significant adverse immune system aberration, the unique immune modulating properties of the cells can bring improvements within the malfunctioning immune system. Stem cells also activate the restorative mechanisms of the damaged brain tissues, which help their functional recovery.
Stem cell therapy, as given by NeuroGen Brain and Spine Institute, use the autologous stem cells for therapeutic purposes. As the cells are derived from the body of the patient itself, there is no danger of immune rejection. NGBSI is an ISO certified institute and offers cellular therapy for Autism treatment in a very hygienic and secure environment.
